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Uses
Phendimetrazine is a sympathomimetic amine, which
is similar to an amphetamine. It is also known
as an "anorectic" or "anorexigenic" drug. Phendimetrazine
stimulates the central nervous system (nerves
and brain), which increases your heart rate and
blood pressure and decreases your appetite. Phendimetrazine
is used as a short-term supplement to diet and
exercise in the treatment of obesity. Phendimetrazine
may also be used for purposes other than those
listed in this medication guide.
How to Use
Take phendimetrazine exactly as directed by your
doctor. If you do not understand these directions,
ask your pharmacist, nurse, or doctor to explain
them to you. Take each dose with a full glass
of water. Phendimetrazine is usually taken once
a day (sustained release formula) or two to three
times daily (immediate-release formula) before
meals on an empty stomach. Do not take phendimetrazine
in the evening because it may cause insomnia.
Do not crush, chew, or open any "once-daily" phendimetrazine
tablets or capsules. Swallow them whole. Never
take more of this medication than is prescribed
for you. Too much phendimetrazine could be very
dangerous to your health.
Side Effects
If you experience any of the following serious
side effects, stop taking phendimetrazine and
seek emergency medical attention: an allergic
reaction (difficulty breathing; closing of your
throat; swelling of your lips, tongue, or face;
or hives); an irregular heartbeat or very high
blood pressure (severe headache, blurred vision);
or hallucinations, abnormal behavior, or confusion.
Other, less serious side effects may be more likely
to occur. Continue to take phendimetrazine and
talk to your doctor if you experience restlessness
or tremor, nervousness or anxiety, headache or
dizziness, insomnia, dry mouth or an unpleasant
taste in your mouth, diarrhea or constipation,
or impotence or changes in your sex drive. Phendimetrazine
is habit forming. You can become physically and
psychologically dependent on this medication,
and withdrawal effects may occur if you stop taking
it suddenly after several weeks of continuous
use. Talk to your doctor about stopping this medication
gradually. Side effects other than those listed
here may also occur. Talk to your doctor about
any side effect that seems unusual or that is
especially bothersome.
Precautions
Use caution when driving, operating machinery,
or performing other hazardous activities. Phendimetrazine
(generic Bontril) may cause dizziness, blurred
vision, or restlessness, and it may hide the symptoms
of extreme tiredness. If you experience these
effects, avoid hazardous activities. Phendimetrazine
is habit forming. You can become physically and
psychologically dependent on this medication,
and withdrawal effects may occur if you stop taking
it suddenly after several weeks of continuous
use. Talk to your doctor about stopping this medication
gradually. Do not crush, chew, or open any "once-daily"
phendimetrazine tablets or capsules. Swallow them
whole.
Drug Interactions
You cannot take phendimetrazine if you have taken
a monoamine oxidase inhibitor (MAOI) such as isocarboxazid
(Marplan), tranylcypromine (Parnate), or phenelzine
(Nardil) in the last 14 days. Changes in insulin
and other diabetes drug therapies may be necessary
during treatment with phendimetrazine. Phendimetrazine
may reduce the effects of guanethidine (Ismelin).
This could lead to an increase in blood pressure.
Tell your doctor if you are taking guanethidine.
Before taking this medication, tell your doctor
if you are taking a tricyclic antidepressant such
as amitriptyline (Elavil), amoxapine (Asendin),
doxepin (Sinequan), nortriptyline (Pamelor), imipramine
(Tofranil), clomipramine (Anafranil), protriptyline
(Vivactil), or desipramine (Norpramin). These
drugs may decrease the effects of phendimetrazine.
Drugs other than those listed here may also interact
with phendimetrazine. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter
medicines.
Overdose
Seek emergency medical attention. Symptoms of
a phendimetrazine overdose include restlessness,
tremor, rapid breathing, confusion, hallucinations,
panic, aggressiveness, nausea, vomiting, diarrhea,
an irregular heartbeat, and seizures.
Missed Dose
Take the missed dose as soon as you remember.
However, if it is almost time for your next dose
or if it is already evening, skip the missed dose
and take only your next regularly scheduled dose.
A dose taken too late in the day will cause insomnia.
Do not take a double dose of this medication.
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